NCSTN Polyclonal Antibody | G-AB-09644

NCSTN Polyclonal Antibody | G-AB-09644 | Gentaur Antibodies

Overview: This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Stem Cells

Synonyms: NCSTN, ATAG1874, nicastrin

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 23385

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human NCSTN (NP_056146.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q92542

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NCSTN Polyclonal Antibody DataSheet