NOTCH1 Polyclonal Antibody | G-AB-09771

NOTCH1 Polyclonal Antibody | G-AB-09771 | Gentaur Antibodies

Overview: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Developmental Biology, Neuroscience, Stem Cells

Synonyms: AOS5, AOVD1, TAN1, hN1, NOTCH1, Activated NOTCH1, notch 1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4851

Accession #:

Clonality:

Immunogen: Recombinant protein of human NOTCH1.

Clone #:

Conjugation: Unconjugated

Swissprot: P46531

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NOTCH1 Polyclonal Antibody DataSheet