NOTCH1 Polyclonal Antibody | G-AB-01454
Gentaur Antibodies
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Gentaur Antibodies
NOTCH1 Polyclonal Antibody | G-AB-01454
- SKU:
- G-AB-01454
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Rat
NOTCH1 Polyclonal Antibody | G-AB-01454 | Gentaur Antibodies
Overview: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Developmental Biology, Neuroscience, Stem Cells
Synonyms: hN1, Neurogenic locus Notch homolog protein 1, NICD, NOTC1, Notch 1, Notch 1 intracellular domain, Notch homolog 1 translocation associated (Drosophila) , notch1, TAN1, Translocation-associated notch protein TAN-1
Reactivity: Human, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP_060087
Clonality: Polyclonal
Immunogen: Synthetic peptide of human NOTCH1
Clone #:
Conjugation: Unconjugated
Swissprot: P46531
Santa Cruz: sc-6014/sc-23299/sc-23301/sc-23304/sc-9170
Calculated MW: 273 kDa
Observed MW:
Concentration: 0.4 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:500-1:2000, IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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