NOTCH3 Polyclonal Antibody | G-AB-08300

NOTCH3 Polyclonal Antibody | G-AB-08300 | Gentaur Antibodies

Overview: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells

Synonyms: NOTCH3, CADASIL, CADASIL1, CASIL, IMF2, LMNS, notch 3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4854

Accession #:

Clonality:

Immunogen: A synthetic peptide of human NOTCH3 (NP_000426.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9UM47

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NOTCH3 Polyclonal Antibody DataSheet