NPHP1 Polyclonal Antibody | G-AB-06748

NPHP1 Polyclonal Antibody | G-AB-06748 | Gentaur Antibodies

Overview: This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cell Biology, Signal Transduction

Synonyms: JBTS4, Juvenile nephronophthisis 1 protein, Nephrocystin 1, nephronophthisis 1 (juvenile) , Nephronophthisis, NPH1, NPHP1, SLSN1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC009789

Clonality: Polyclonal

Immunogen: Fusion protein of human NPHP1

Clone #:

Conjugation: Unconjugated

Swissprot: O15259

Santa Cruz:

Calculated MW: 83 kDa

Observed MW: Refer to figures

Concentration: 1.02 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NPHP1 Polyclonal Antibody DataSheet