NPHS1 Polyclonal Antibody | G-AB-05355

NPHS1 Polyclonal Antibody | G-AB-05355 | Gentaur Antibodies

Overview: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: CNF, Nephrin, Nephrosis 1 congenital Finnish type, Nephrosis 1, congenital, Finnish type (nephrin) , NPHN, NPHN, NPHS 1, Nphs1, Renal glomerulus specific cell adhesion receptor, Renal glomerulus-specific cell adhesion receptor

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Nephrin

Clone #:

Conjugation: Unconjugated

Swissprot: Q9QZS7

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.3 mg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:1000-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NPHS1 Polyclonal Antibody DataSheet