NPRL2 Polyclonal Antibody | G-AB-10872

NPRL2 Polyclonal Antibody | G-AB-10872 | Gentaur Antibodies

Overview: NPRL2, also known as TUSC4 (tumor suppressor candidate 4) , is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: NPRL2, FFEVF2, NPR2, NPR2L, TUSC4, NPR2-like

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 10641

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human NPRL2 (NP_006536.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q8WTW4

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NPRL2 Polyclonal Antibody DataSheet