NR0B2 Polyclonal Antibody | G-AB-09780

NR0B2 Polyclonal Antibody | G-AB-09780 | Gentaur Antibodies

Overview: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction

Synonyms: NR0B2, SHP, SHP1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 8431

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human NR0B2 (NP_068804.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q15466

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:10-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NR0B2 Polyclonal Antibody DataSheet