ORC2 Polyclonal Antibody | G-AB-09152

ORC2 Polyclonal Antibody | G-AB-09152 | Gentaur Antibodies

Overview: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: ORC2, ORC2L

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 4999

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ORC2 (NP_006181.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13416

Santa Cruz:

Calculated MW: 65 kDa

Observed MW: 80 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ORC2 Polyclonal Antibody DataSheet