P21 Polyclonal Antibody | G-AB-00054
Gentaur Antibodies
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Gentaur Antibodies
P21 Polyclonal Antibody | G-AB-00054
- SKU:
- G-AB-00054
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
P21 Polyclonal Antibody | G-AB-00054 | Gentaur Antibodies
Overview: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739) .
Category Type: Polyclonal Antibody
Research Areas: Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction
Synonyms: CDKI, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CIZ1, CIZ1, cyclin dependent inhibitor 1A, LSFR1, Melanoma differentiation-associated protein, NP94, Nuclear protein NP94, OPHN3, P21, Zinc finger protein 356, ZNF356
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID: 1026
Accession #:
Clonality: Polyclonal
Immunogen: Recombinant Human P21 protein
Clone #:
Conjugation: Unconjugated
Swissprot: P38936
Santa Cruz: sc-471, sc-469, sc-397, sc-756
Calculated MW: 18 kDa
Observed MW: 18 kDa
Concentration: 2 mg/mL
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification method: Affinity purification
Application: WB
Dilution: WB 1:500-1:1000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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