p21 Polyclonal Antibody | G-AB-05227

p21 Polyclonal Antibody | G-AB-05227 | Gentaur Antibodies

Overview: CDKN1A (p21, CIP1, WAF1) , a cyclin-dependent kinase inhibitor, is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA) , and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: CAP20, CDK-interacting protein 1, CDKI, CDKN1, Cdkn1a, CDN1A, CIP1, Cyclin Dependent Kinase Inhibitor 1A, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1A (P21) , Cyclin-dependent kinase inhibitor 1A (p21, Cip1) , DNA Synthesis Inhibitor, MDA-6, MDA6, Melanoma differentiation-associated protein 6, Melanoma differentiation-associated protein, p21, P21 protein, p21CIP1, p21Cip1/Waf1, p21WAF, PIC1, SDI1, SLC12A9, WAF1, Wild type p53 activated fragment 1 (WAF1) , Wild type p53 activated fragment 1, Wildtype p53-activated fragment 1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse P21

Clone #:

Conjugation: Unconjugated

Swissprot: P38936, P39689

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.7 mg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:200-1:800

Storage: Store at -20°C. Avoid freeze / thaw cycles.

p21 Polyclonal Antibody DataSheet