p21 Polyclonal Antibody | G-AB-08829

p21 Polyclonal Antibody | G-AB-08829 | Gentaur Antibodies

Overview: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, CDKN1A

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1026

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human p21 (NP_000380.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P38936

Santa Cruz:

Calculated MW: 21 kDa

Observed MW: 21 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

p21 Polyclonal Antibody DataSheet