p53RFP Polyclonal Antibody | G-AB-02553
Gentaur Antibodies
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Gentaur Antibodies
p53RFP Polyclonal Antibody | G-AB-02553
- SKU:
- G-AB-02553
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
p53RFP Polyclonal Antibody | G-AB-02553 | Gentaur Antibodies
Overview: p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP) , an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
Category Type: Polyclonal Antibody
Research Areas: Cell Biology
Synonyms: bA528A10.3, E3 ubiquitin protein ligase RNF144B, E3 ubiquitin-protein ligase RNF144B, IBR domain containing 2, IBR domain containing protein 2, IBR domain-containing protein 2, IBRDC 2, IBRDC2, KIAA0161, MGC71786, OTTHUMP00000016079, OTTHUMP00000016080, OTTHUMP00000039360, p53 inducible RING finger protein, p53-inducible RING finger protein, p53RFP, PIR2, R144B, Ring finger 144B, RING finger protein 144B, RNF 144B, RNF144B
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: BC063311
Clonality: Polyclonal
Immunogen: Recombinant protein of human RNF144B
Clone #:
Conjugation: Unconjugated
Swissprot: Q7Z419
Santa Cruz: sc-33015/sc-33017/sc-67015/sc-67014
Calculated MW: 34 kDa
Observed MW:
Concentration: 0.4 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:200-1:1000, IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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