PABPN1 Polyclonal Antibody | G-AB-10921

PABPN1 Polyclonal Antibody | G-AB-10921 | Gentaur Antibodies

Overview: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly (A) tails. The protein is required for progressive and efficient polymerization of poly (A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly (A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly (A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: PABPN1, OPMD, PAB2, PABII, PABP-2, PABP2

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 8106

Accession #:

Clonality:

Immunogen: A synthetic peptide of human PABPN1 (NP_004634.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q86U42

Santa Cruz:

Calculated MW: 31 kDa/32 kDa/37 kDa

Observed MW: 45 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PABPN1 Polyclonal Antibody DataSheet