PAX5 Polyclonal Antibody | G-AB-01373

PAX5 Polyclonal Antibody | G-AB-01373 | Gentaur Antibodies

Overview: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9;14) (p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms: B cell lineage specific activator, B cell lineage specific activator protein, B cell specific activator protein, B cell specific transcription factor, B-cell-specific transcription factor, BSAP, EBB-1, KLP, Paired box 5, Paired box gene 5 (B cell lineage specific activator protein) , Paired box gene 5 (B cell lineage specific activator) , Paired box gene 5, Paired box homeotic gene 5, Paired box protein Pax 5, Paired box protein Pax-5, Paired domain gene 5, PAX 5, PAX5, PAX5, Transcription factor PAX 5

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_057953

Clonality: Polyclonal

Immunogen: Synthetic peptide of human PAX5

Clone #:

Conjugation: Unconjugated

Swissprot: Q02548

Santa Cruz: sc-1974/sc-1975/sc-55515

Calculated MW: 42 kDa

Observed MW:

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PAX5 Polyclonal Antibody DataSheet