PDE6A Polyclonal Antibody | G-AB-11942

PDE6A Polyclonal Antibody | G-AB-11942 | Gentaur Antibodies

Overview: This gene encodes the cyclic-GMP (cGMP) -specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: PDE6A, CGPR-A, PDEA, RP43

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5145

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PDE6A (NP_000431.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P16499

Santa Cruz:

Calculated MW: 99 kDa

Observed MW: 120 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PDE6A Polyclonal Antibody DataSheet