PDHA1 Polyclonal Antibody | G-AB-09815

PDHA1 Polyclonal Antibody | G-AB-09815 | Gentaur Antibodies

Overview: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2) , and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1) , dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) . The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: PDHA1, PDHA, PDHAD, PDHCE1A, PHE1A

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5160

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PDHA1 (NP_000275.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P08559

Santa Cruz:

Calculated MW: 40 kDa/43 kDa/44 kDa/47 kDa

Observed MW: 45 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PDHA1 Polyclonal Antibody DataSheet