PERK Polyclonal Antibody | G-AB-05492

PERK Polyclonal Antibody | G-AB-05492 | Gentaur Antibodies

Overview: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) , leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER) , where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms: DKFZp781H1925, E2AK3, EC 2.7.11.1, Eif2ak3, Eukaryotic translation initiation factor 2 alpha kinase 3, Eukaryotic translation initiation factor 2-alpha kinase 3, Heme regulated EIF2 alpha kinase, HRI, HsPEK, Pancreatic eIF2 alpha kinase, Pancreatic eIF2-alpha kinase, PEK, PRKR like endoplasmic reticulum kinase, PRKR-like endoplasmic reticulum kinase, WRS

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant protein corresponding to Mouse PERK

Clone #:

Conjugation: Unconjugated

Swissprot: Q9Z2B5, Q9NZJ5

Santa Cruz:

Calculated MW: 140 kDa

Observed MW: 140 kDa

Concentration: 100 μg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PERK Polyclonal Antibody DataSheet