Phospho-ABL1 (Y412) Polyclonal Antibody | G-AB-12617
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-ABL1 (Y412) Polyclonal Antibody | G-AB-12617 | Gentaur Antibodies
Overview: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410) . Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction
Synonyms: ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, ABL1, c-Abl, bcr/abl
Reactivity: Human, Mouse, Rat
Gene ID: 25
Immunogen: A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1.
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.