Phospho-ABL1 (Y412) Polyclonal Antibody | G-AB-12617

Phospho-ABL1 (Y412) Polyclonal Antibody | G-AB-12617 | Gentaur Antibodies

Overview: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t (9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410) . Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, ABL1, c-Abl, bcr/abl

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 25

Accession #:

Clonality:

Immunogen: A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1.

Clone #:

Conjugation: Unconjugated

Swissprot: P00519

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-ABL1 (Y412) Polyclonal Antibody DataSheet