Phospho-AKT1 (Ser473) Monoclonal Antibody | G-AB-05842
- 3 to 5 Working Days
Phospho-AKT1 (Ser473) Monoclonal Antibody | G-AB-05842 | Gentaur Antibodies
Overview: The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Synonyms: AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha
Immunogen: Synthetic Peptide of Phospho-Akt (S473)
Clone #: Clone:7F9
Observed MW: 60 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification method: Protein A purification
Application: WB, IHC-p
Dilution: WB 1:1000-2000, IHC 1:100-200
Storage: Store at -20°C. Avoid freeze / thaw cycles.