Phospho-BRCA1 (S1423) Polyclonal Antibody | G-AB-12536
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-BRCA1 (S1423) Polyclonal Antibody | G-AB-12536 | Gentaur Antibodies
Overview: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) . This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Synonyms: BRCA1, BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Reactivity: Human, Mouse, Rat
Gene ID: 672
Immunogen: A synthetic phosphorylated peptide around S1423 of human BRCA1 (NP_009225.1) .
Calculated MW: 7 kDa/78-85 kDa/202-210 kDa
Observed MW: 270 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC, IF
Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.