Phospho-Catenin beta (Tyr654) Polyclonal Antibody | G-AB-05743

Phospho-Catenin beta (Tyr654) Polyclonal Antibody | G-AB-05743 | Gentaur Antibodies

Overview: Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Synonyms: Beta catenin, Beta-catenin, Cadherin associated protein, Catenin (cadherin associated protein) , beta 1, 88kDa, Catenin beta 1, Catenin beta-1, CATNB, CHBCAT, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human Catenin-β around the phosphorylation site of Tyr654

Clone #:

Conjugation: Unconjugated

Swissprot: P35222

Santa Cruz:

Calculated MW: 85 kDa

Observed MW: 75 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, ELISA

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-Catenin beta (Tyr654) Polyclonal Antibody DataSheet

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