Phospho-β-catenin (S33/S37/T41) Polyclonal Antibody | G-AB-12587

Phospho-β-catenin (S33/S37/T41) Polyclonal Antibody | G-AB-12587 | Gentaur Antibodies

Overview: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC) , pilomatrixoma (PTR) , medulloblastoma (MDB) , and ovarian cancer. Alternative splicing results in multiple transcript variants.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Synonyms: CTNNB, MRD19, armadillo, beta Catenin, CTNNB1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1499

Accession #:

Clonality:

Immunogen: A synthetic phosphorylated peptide around S33 & T41 of human beta Catenin (NP_001091679) .

Clone #:

Conjugation: Unconjugated

Swissprot: P35222

Santa Cruz:

Calculated MW: 9 kDa/85 kDa

Observed MW: 85 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-β-catenin (S33/S37/T41) Polyclonal Antibody DataSheet