Phospho-β-catenin (S33/S37/T41) Polyclonal Antibody | G-AB-12587
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-β-catenin (S33/S37/T41) Polyclonal Antibody | G-AB-12587 | Gentaur Antibodies
Overview: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC) , pilomatrixoma (PTR) , medulloblastoma (MDB) , and ovarian cancer. Alternative splicing results in multiple transcript variants.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells
Synonyms: CTNNB, MRD19, armadillo, beta Catenin, CTNNB1
Reactivity: Human, Mouse, Rat
Gene ID: 1499
Immunogen: A synthetic phosphorylated peptide around S33 & T41 of human beta Catenin (NP_001091679) .
Calculated MW: 9 kDa/85 kDa
Observed MW: 85 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.