Phospho-MET (Y1003) Polyclonal Antibody | G-AB-12498

Phospho-MET (Y1003) Polyclonal Antibody | G-AB-12498 | Gentaur Antibodies

Overview: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: MET, AUTS9, DFNB97, HGFR, RCCP2, c-Met

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4233

Accession #:

Clonality:

Immunogen: A synthetic phosphorylated peptide around Y1003 of human MET (NP_000236.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P08581

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:20-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-MET (Y1003) Polyclonal Antibody DataSheet