Phospho-MYC (S62) Polyclonal Antibody | G-AB-12503

Phospho-MYC (S62) Polyclonal Antibody | G-AB-12503 | Gentaur Antibodies

Overview: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms: MRTL, MYCC, bHLHe39, c-Myc, MYC

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4609

Accession #:

Clonality:

Immunogen: A phospho specific peptide corresponding to residues surrounding S62 of human MYC

Clone #:

Conjugation: Unconjugated

Swissprot: P01106

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-MYC (S62) Polyclonal Antibody DataSheet