Phospho-NFKB1 (S337) Polyclonal Antibody | G-AB-12518

Phospho-NFKB1 (S337) Polyclonal Antibody | G-AB-12518 | Gentaur Antibodies

Overview: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Synonyms: NFKB1, CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4790

Accession #:

Clonality:

Immunogen: A phospho specific peptide corresponding to residues surrounding S337 of human NFKB1

Clone #:

Conjugation: Unconjugated

Swissprot: P19838

Santa Cruz:

Calculated MW: 85 kDa/105 kDa

Observed MW: 120 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-NFKB1 (S337) Polyclonal Antibody DataSheet