Phospho-p53 (S46) Polyclonal Antibody | G-AB-12577
- 3 to 5 Working Days
Phospho-p53 (S46) Polyclonal Antibody | G-AB-12577 | Gentaur Antibodies
Overview: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277) .
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Synonyms: BCC7, LFS1, P53, TRP53, p53, TP53, BMFS5
Gene ID: 7157
Immunogen: A synthetic phosphorylated peptide around S46 of human p53 (NP_000537.3) .
Calculated MW: 23-43 kDa
Observed MW: 44 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:1000-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.