Phospho-POLR2A (S5) Polyclonal Antibody | G-AB-12606

Phospho-POLR2A (S5) Polyclonal Antibody | G-AB-12606 | Gentaur Antibodies

Overview: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: POLR2A, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, Pol II

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5430

Accession #:

Clonality:

Immunogen: A phospho specific peptide corresponding to residues surrounding S5 of human POLR2A

Clone #:

Conjugation: Unconjugated

Swissprot: P24928

Santa Cruz:

Calculated MW: 63 kDa/217 kDa

Observed MW: 260 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-POLR2A (S5) Polyclonal Antibody DataSheet