Phospho-RAF1 (S259) Polyclonal Antibody | G-AB-12583
- 3 to 5 Working Days
- Human, Mouse
Phospho-RAF1 (S259) Polyclonal Antibody | G-AB-12583 | Gentaur Antibodies
Overview: This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K) , which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cell Biology, Metabolism, Signal Transduction
Synonyms: CMD1NN, CRAF, NS5, Raf-1, c-Raf, RAF1
Reactivity: Human, Mouse
Gene ID: 5894
Immunogen: A synthetic phosphorylated peptide around S259 of human RAF1 (NP_002871.1) .
Calculated MW: 73 kDa/75 kDa
Observed MW: 73 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.