Phospho-RAF1 (S621) Polyclonal Antibody | G-AB-12506

Phospho-RAF1 (S621) Polyclonal Antibody | G-AB-12506 | Gentaur Antibodies

Overview: This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K) , which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms: CMD1NN, CRAF, NS5, Raf-1, c-Raf, RAF1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 5894

Accession #:

Clonality:

Immunogen: A synthetic phosphorylated peptide around S621 of human RAF1 (NP_002871.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P04049

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-RAF1 (S621) Polyclonal Antibody DataSheet