Phospho-RB1 (S780) Polyclonal Antibody | G-AB-12564

Phospho-RB1 (S780) Polyclonal Antibody | G-AB-12564 | Gentaur Antibodies

Overview: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) , bladder cancer, and osteogenic sarcoma.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1, Rb

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5925

Accession #:

Clonality:

Immunogen: A phospho specific peptide corresponding to residues surrounding S780 of human RB1

Clone #:

Conjugation: Unconjugated

Swissprot: P06400

Santa Cruz:

Calculated MW: 106 kDa

Observed MW: 100 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-RB1 (S780) Polyclonal Antibody DataSheet