Phospho-SMAD3 (Ser425) Monoclonal Antibody | G-AB-05840

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$163.00 - $465.00
SKU:
G-AB-05840
Availability:
3 to 5 Working Days
Host:
Mouse
Reactivity:
Human, Mouse, Rat
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Phospho-SMAD3 (Ser425) Monoclonal Antibody | G-AB-05840 | Gentaur Antibodies

Overview: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction, Stem Cells

Synonyms: DKFZP586N0721, DKFZp686J10186, hMAD 3, hMAD-3, hSMAD3, HSPC193, HST17436, JV15 2, JV15-2, JV152, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, Mad homolog JV15 2, Mad protein homolog, MAD, mothers against decapentaplegic homolog 3, Mad3, MADH 3, MADH3, MGC60396, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMA and MAD related protein 3, SMAD 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, Smad3, SMAD3

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Synthetic Peptide of Phospho-Smad3 (Ser425)

Clone #: Clone:4C5

Conjugation: Unconjugated

Swissprot: P84022

Santa Cruz: sc-8332

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification method: Protein A purification

Application: IHC-p

Dilution: IHC 1:50-300

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-SMAD3 (Ser425) Monoclonal Antibody DataSheet

Citation #1

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