Phospho-SRC Family（Y416） Polyclonal Antibody | G-AB-12580
- 3 to 5 Working Days
Phospho-SRC Family（Y416） Polyclonal Antibody | G-AB-12580 | Gentaur Antibodies
Overview: This gene is a member of the Src family of protein tyrosine kinases (PTKs) . The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. /This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Category Type: Phosphorylated antibody
Synonyms: Src Family
Gene ID: 3932/2534
Immunogen: A phospho specific peptide corresponding to residues surrounding Y416 of human SRC Family
Swissprot: P06239, P06241
Calculated MW: 40 kDa/58 kDa/61 kDa/54 kDa/60 kDa
Observed MW: 58 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.