PHOX2B Polyclonal Antibody | G-AB-12387
- 3 to 5 Working Days
- Human, Mouse, Rat
PHOX2B Polyclonal Antibody | G-AB-12387 | Gentaur Antibodies
Overview: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience
Synonyms: PHOX2B, NBLST2, NBPhox, PMX2B
Reactivity: Human, Mouse, Rat
Gene ID: 8929
Immunogen: Recombinant fusion protein of human PHOX2B (NP_003915.2) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.