PLK3 Polyclonal Antibody | G-AB-12303

PLK3 Polyclonal Antibody | G-AB-12303 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction

Synonyms: PLK3, CNK, FNK, PLK-3, PRK

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1263

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PLK3 (NP_004064.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9H4B4

Santa Cruz:

Calculated MW: 71 kDa

Observed MW: 82 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PLK3 Polyclonal Antibody DataSheet