PMS2 Polyclonal Antibody | G-AB-08395

PMS2 Polyclonal Antibody | G-AB-08395 | Gentaur Antibodies

Overview: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X) 2E (X) 4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: PMS2, HNPCC4, MLH4, PMS2CL, PMSL2

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 5395

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PMS2 (NP_000526.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P54278

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PMS2 Polyclonal Antibody DataSheet