PRKACA Polyclonal Antibody | G-AB-00167

PRKACA Polyclonal Antibody | G-AB-00167 | Gentaur Antibodies

Overview: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: cAMP dependent protein kinase alpha catalytic subunit, cAMP dependent protein kinase beta catalytic subunit, cAMP dependent protein kinase catalytic beta subunit isoform 4ab, cAMP dependent protein kinase catalytic subunit alpha, cAMP dependent protein kinase catalytic subunit alpha, isoform 1, cAMP dependent protein kinase catalytic subunit beta, cAMP-dependent protein kinase catalytic subunit alpha, KAPCA, PKA C alpha, PKA C beta, PKA C-alpha, PKACA, PKACB, PPNAD4, PRKACA, PRKACAA, PRKACB, Protein kinase A catalytic subunit alpha, Protein kinase A catalytic subunit, Protein kinase A catalytic subunit beta, Protein kinase cAMP dependent catalytic alpha, Protein kinase cAMP dependent catalytic beta

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant Mouse cAMP-dependent protein kinase catalytic subunit alpha protein

Clone #:

Conjugation: Unconjugated

Swissprot: P05132

Santa Cruz:

Calculated MW: 39 kDa

Observed MW: 39 kDa

Concentration: 2 mg/mL

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PRKACA Polyclonal Antibody DataSheet