PRKAR2A Polyclonal Antibody | G-AB-06150

PRKAR2A Polyclonal Antibody | G-AB-06150 | Gentaur Antibodies

Overview: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: cAMP dependent protein kinase regulatory subunit alpha 2, cAMP dependent protein kinase regulatory subunit RII alpha, cAMP dependent protein kinase type II alpha regulatory chain, cAMP dependent protein kinase type II alpha regulatory subunit, cAMP-dependent protein kinase type II-alpha regulatory subunit, KAP2, KAP2, MGC3606, PKR 2, PKR2, PRKA R2, PRKAR 2, PRKAR2, PRKAR2A, Protein kinase A RII alpha subunit, Protein kinase cAMP dependent regulatory type II alpha

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC002763

Clonality: Polyclonal

Immunogen: Fusion protein of human PRKAR2A

Clone #:

Conjugation: Unconjugated

Swissprot: P13861

Santa Cruz:

Calculated MW: 46 kDa

Observed MW: Refer to figures

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:35-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PRKAR2A Polyclonal Antibody DataSheet