PSEN1 Polyclonal Antibody | G-AB-10001

PSEN1 Polyclonal Antibody | G-AB-10001 | Gentaur Antibodies

Overview: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms: AD3, FAD, PS-1, PS1, S182, Presenilin 1, PSEN1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5663

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PSEN1 (NP_015557.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P49768

Santa Cruz:

Calculated MW: 21 kDa/42 kDa/46 kDa/48 kDa/52 kDa

Observed MW: 52 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PSEN1 Polyclonal Antibody DataSheet