PSENEN Polyclonal Antibody | G-AB-08976

PSENEN Polyclonal Antibody | G-AB-08976 | Gentaur Antibodies

Overview: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2) . Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: PSENEN, MDS033, MSTP064, PEN-2, PEN2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 55851

Accession #:

Clonality:

Immunogen: A synthetic peptide of human PSENEN (NP_758844.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9NZ42

Santa Cruz:

Calculated MW: 12 kDa

Observed MW: 16 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PSENEN Polyclonal Antibody DataSheet