PSME2 Polyclonal Antibody | G-AB-08369

PSME2 Polyclonal Antibody | G-AB-08369 | Gentaur Antibodies

Overview: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology

Synonyms: PSME2, PA28B, PA28beta, REGbeta

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 5721

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human PSME2 (NP_002809.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9UL46

Santa Cruz:

Calculated MW: 27 kDa

Observed MW: 27 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PSME2 Polyclonal Antibody DataSheet