PTEN Monoclonal Antibody | G-AB-05707

PTEN Monoclonal Antibody | G-AB-05707 | Gentaur Antibodies

Overview: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns (3, 4, 5) P3 > PtdIns (3, 4) P2 > PtdIns3P > Ins (1, 3, 4, 5) P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

Category Type: Monoclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction

Synonyms: 10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, Phosphatase and tensin like protein, Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Pten, PTEN, PTEN1, TEP1

Reactivity: Human

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Synthetic Peptide of PTEN

Clone #: Clone:9E8

Conjugation: Unconjugated

Swissprot: P60484

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Protein A purification

Application: IHC-p

Dilution: IHC 1:100-200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PTEN Monoclonal Antibody DataSheet