PTPRC Polyclonal Antibody | G-AB-09951

PTPRC Polyclonal Antibody | G-AB-09951 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Immunology, Neuroscience, Signal Transduction, Stem Cells

Synonyms: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, PTPRC

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5788

Accession #:

Clonality:

Immunogen: A synthetic peptide of human PTPRC (NP_002829.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P08575

Santa Cruz:

Calculated MW: 130 kDa/147 kDa

Observed MW: 185 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PTPRC Polyclonal Antibody DataSheet