PTTG1 Polyclonal Antibody | G-AB-01382

PTTG1 Polyclonal Antibody | G-AB-01382 | Gentaur Antibodies

Overview: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: EAP1, PTTG, HPTTG, TUTR1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_004210.1

Clonality: Polyclonal

Immunogen: Synthetic peptide of human PTTG1

Clone #:

Conjugation: Unconjugated

Swissprot: O95997

Santa Cruz: sc-5843/sc-5836/sc-5837/sc-5839/sc-67817/sc-22772

Calculated MW:

Observed MW:

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:100-1:300

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PTTG1 Polyclonal Antibody DataSheet