PXR Polyclonal Antibody | G-AB-09217

PXR Polyclonal Antibody | G-AB-09217 | Gentaur Antibodies

Overview: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 8856

Accession #:

Clonality:

Immunogen: A synthetic peptide of human PXR (NP_071285.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O75469

Santa Cruz:

Calculated MW: 39 kDa/43 kDa/45 kDa/48 kDa/49 kDa/52 kDa/53 kDa

Observed MW: 49 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

PXR Polyclonal Antibody DataSheet