Rb Polyclonal Antibody | G-AB-07545
- 3 to 5 Working Days
- Human, Mouse
Rb Polyclonal Antibody | G-AB-07545 | Gentaur Antibodies
Overview: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) , bladder cancer, and osteogenic sarcoma.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Synonyms: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1, Rb
Reactivity: Human, Mouse
Gene ID: 5925
Immunogen: Recombinant fusion protein of human Rb (NP_000312.2) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IF 1:100-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.