RBFOX3 Polyclonal Antibody | G-AB-05408

RBFOX3 Polyclonal Antibody | G-AB-05408 | Gentaur Antibodies

Overview: Immunoprecipitation and mass spectrometry of the two major NeuN species at 45–50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors) , confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Tags & Cell Markers

Synonyms: FLJ56884, FLJ58356, Fox-1 homolog C, fox1 homolog C, Fox3, FOX3NeuN, hexaribonucleotide binding protein 3, HRNBP3, NEUN, neuronal nuclei, Rbfox3, RFOX3, RNA binding protein fox-1 homolog 3, RNA binding protein, fox 1 homolog (C. elegans) 3

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to NeuN

Clone #:

Conjugation: Unconjugated

Swissprot: Q8BIF2

Santa Cruz:

Calculated MW: 46-48 kDa

Observed MW: 46-48 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000, IHC 1:300-1:800

Storage: Store at -20°C. Avoid freeze / thaw cycles.

RBFOX3 Polyclonal Antibody DataSheet

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