SETDB1 Polyclonal Antibody | G-AB-06659

SETDB1 Polyclonal Antibody | G-AB-06659 | Gentaur Antibodies

Overview: SETDB1, also named as ESET, KIAA0067 and KMT1E, belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation, gene silencing, and transcriptional repression. It has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: AU022152, EC 2.1.1.43, ERG-associated protein with SET domain, ESET, H3 K9 HMTase 4, H3-K9-HMTase 4, H3-K9-HMTase4, Histone H3 K9 methyltransferase 4, Histone H3-K9 methyltransferase 4, Histone-lysine N-methyltransferase SETDB1, KG1T, KIAA0067, KMT1E, Lysine N-methyltransferase 1E, MGC90670, mKIAA0067, SET domain bifurcated 1, Set domain protein, bifurcated, 1, SETB1, Setdb1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC009362

Clonality: Polyclonal

Immunogen: Fusion protein of human SETDB1

Clone #:

Conjugation: Unconjugated

Swissprot: Q15047

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.08 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SETDB1 Polyclonal Antibody DataSheet