SHC1 Polyclonal Antibody | G-AB-11830

SHC1 Polyclonal Antibody | G-AB-11830 | Gentaur Antibodies

Overview: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in Signal Transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Signal Transduction

Synonyms: SHC, SHCA, SHC1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 6464

Accession #:

Clonality:

Immunogen: A synthetic peptide of human SHC1

Clone #:

Conjugation: Unconjugated

Swissprot: P29353

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SHC1 Polyclonal Antibody DataSheet